As with other μ-opioid agonists, tapentadol might trigger spasms in the sphincter of Oddi, and is also for that reason discouraged for use in patients with biliary tract disease which include both equally acute and Continual pancreatitis. People who are immediate or extremely fast metabolizers with the CYP2C9, CYP2C19, and CYP2D6 enzymes might not